Head and neck cancers (HNC) are indicated when cells grow abnormally. The disturbing rate of morbidity and mortality of patients with HNC due to late presentation is on the increase especially in Africa (developing countries). There is need to diagnose head and neck cancer early if patients present so that prompt referral could be facilitated. The collected data consists of 1473 instances with 18 features. The dataset was divided into training and test data. Two supervised learning algorithms were deployed for the study namely: Decision Tree (C4.5) and k-Nearest Neighbors (KNN). It showed that Decision Tree outperformed with accuracy of 91.40% while KNN had accuracy of 88.24%. Hence, machine learning algorithm like Decision Tree can be used for diagnosis of HNC in healthcare organisations.
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